Clinical Evidence

The evidence is clear. Multiple research studies have shown how NIRS Imaging can help identify lipid core plaque (LCP), an underlying cause of serious cardiac events.

PACMAN-AMI Randomized Clinical Trial: Shows Reduced Plaque Regression in AMI Patients Treated with Alirocumab Principal Investigator:Lorenz Räber, MD, PhD View ACC Presentation View JAMA Abstract
PROSPECT II & PROSPECT ABSORB Study: The Detection and Treatment of Vulnerable Plaques Co-Primary Investigator: David Erlinge, MD, PhD Co-Primary Investigator: Gregg W. Stone, MD

Presented at TCT Connect, the 32nd annual scientific symposium of the Cardiovascular Research Foundation.

Lipid Rich Plaque (LRP) Study: Assessment of Coronary Near-Infrared Spectroscopy Imaging to Detect Vulnerable Plaques and Vulnerable Patients Principal Investigator:Ron Waksman, MD View LRP Study Overview View The Lancet LRP Study

Near-Infrared Spectroscopy Predicts Cardiovascular Outcome in Patients with Coronary Artery Disease

Oemrawsingh RM, Cheng JM, García-García HM, et al

CAD patients with an LCBI equal to or above the median of 43.0, as assessed by NIRS in a nonculprit coronary artery, had a 4-fold risk of adverse cardiovascular events during 1-year follow-up.

J Am Coll Cardiol. 2014 Dec 16;64(23):2510-8.

Large Lipid-Rich Coronary Plaques Detected by Near-Infrared Spectroscopy at Non-Stented Sites in the Target Artery Identify Patients Likely to Experience Future Major Adverse Cardiovascular Events

Madder RD, Husaini M, Davis AT, et al.

NIRS-derived LCBI is associated with adverse cardiac outcome in CAD patients during long-term follow-up independent of clinical risk factors and plaque burden.

Eur Heart J Cardiovasc Imaging. 2016 Apr;17(4):393-9.

Near-Infrared Spectroscopy-Derived Lipid Core Burden Index Predicts Adverse Cardiovascular Outcome in Patients with Coronary Artery Disease During Long-Term Follow-Up

Schuurman A-S, Vroegindewey M, Kardys I, et al.

Detection of large LRP by NIRS at non-stented sites in a target artery was associated with an increased risk of future MACCE.

Eur Heart J 2017; ehx247, Epub ahead of print.

Long-Term Follow-Up after Near-Infrared Spectroscopy Coronary Imaging: Insights From the Lipid Core Plaque Association with Clinical Events (ORACLE-NIRS) Registry

Danek BA, Karatasakis A, Karacsonyi J, et al.

During long-term follow-up of patients who underwent NIRS imaging, high LCBI in a non-PCI target vessel was associated with increased incidence of MACE.

Cardiovasc Revascularization Med Mol Interv 2017;18(3):177–81.

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